The present invention is based on a plurality of benefits from the extracts of mycelia of individual fungal species, and their mixtures, to provide an armamentarium of defenses from multiple stressors in order to help bees survive and more particularly overcome a complex of symptoms collectively called colony collapse disorder (CCD). The methods and compositions of this designed fungal bioshield helps tilt the balance in favor of bee colony survival, improving the health conditions, disease resistance, pesticide tolerance, pollution tolerance, drought tolerance, pollination abilities, and quality of the honey produced by bees.