A sanitization device comprises an enclosure comprising emitters configured to emit sanitizing electro-optical radiation into an interior compartment. The sanitization device further includes a panel having an open configuration and a closed configuration adapted to enclose the inner compartment. The panel includes an inner surface forming a depression configured to receive a portable device when the panel is in the open configuration and to secure the portable device as the panel transitions to the closed configuration. The sanitization device may further comprise an actuator configured to transition the panel between the open and closed configurations in response to inputs received via a touchless input interface.