B.R.A.I.N. Biotechnology Research and Information Network AG
发明人:
Krohn Michael,Sombroek Dirk
申请号：
US201615226829
公开号：
US10000438(B2)
申请日:
2016.08.02
申请国别(地区):
美国
年份:
2018
代理人:
Morrison & Foerster LLP
摘要：
The present invention relates to the use of compounds which are capable of attenuating skin irritation when they are applied to the skin. Skin irritation can be caused, inter alia, by ingredients of cosmetic or pharmaceutical compositions and/or environmental irritants. In particular, the present invention relates to compounds having the property of antagonizing the activation of the transient receptor potential (TRP) ankyrin 1 (TRPA1) ion channel and the use of said compounds as soothing agents. Such compounds can be used in many fields, particularly in personal-care products, cosmetics, textile and packaging products, pharmaceutical compositions, medical devices, and foodstuffs. The present invention further relates to products and/or pharmaceutical compositions containing said compounds. The present invention also relates to the use of the compounds described herein for the modulation of the taste of a food product.
