A solid dose composition comprising at least one pharmaceutically active ingredient and at least one controlled release agent and method of manufacturing said composition is disclosed. The burst profile of at least one pharmaceutically active ingredient in the composition is regulated by the apparent viscosity of the controlled release agent and wherein at least one pharmaceutically active ingredient is processed by wet granulation.本發明係揭示一種固體劑量組合物，其包含至少一種醫藥活性成份及至少一種控制釋放劑，及揭示一種製備該組合物之方法。組合物中至少一種醫藥活性成份之突釋曲線係藉由控制釋放劑的表觀黏度調節且其中至少一種醫藥活性成份係藉由濕法製粒加工。
