#$%^&*AU2014201478A120141002.pdf#####ABSTRACT A real time image guidance system (100) is provided having an imaging device (102) configured to capture a surface image (138) of tissue and an ultrasound device (104 and 106) configured to capture a sub-surface image (140) of tissue. An imaging processor (108) combines the surface image (138) and the sub-surface image (140) to generate a three-dimensional (3D) image (142) that is displayed to a clinician.1/4 100 10210 Imaging Device 108 110 Cntroler Display 04 T106 Cnrle Jltrasound __Ultrasound Device Controller Fig. 1 108 UltrasoundF Port 130 1,l24 1,l32 Memory Prmceiso Display Port 126 128 Carnera Port Input Device Fig. 3