The present invention relates generally to intranasal pharmaceutical compositions. In particular, the present invention is directed to sustained, enhanced delivery of pharmaceutical agents across the nasal mucosa for systemic drug delivery.L'invention concerne généralement des compositions pharmaceutiques intranasales. Elle concerne en particulier le largage amélioré et prolongé d'agents pharmaceutiques dans l'ensemble de la muqueuse nasale pour largage systémique de médicament.