Garcia, Gabriela,Kubasek, William,Lahdenranta, Maria Johanna,MacBeath, Gavin,McDonagh, Charlotte,Moyo, Victor,Onsum, Matthew David,Sevecka, Mark,Wainszelbaum, Marisa,Zhang, Bo,Schoeberl, Birgit
申请号：
AU2012229062
公开号：
AU2012229062A1
申请日:
2012.03.15
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
Provided are methods for overcoming resistance to an ErbB pathway inhibitor, such as an EGFR inhibitor or a HER2 inhibitor. The resistance may be acquired resistance to an EGFR inhibitor, such as acquired resistance to gefitinib. In the methods provided, a subject exhibiting resistance to an ErbB pathway inhibitor is selected and both an ErbB 3 inhibitor and a second ErbB pathway inhibitor are administered to the subject, such as an EGFR inhibitor or a HER2 inhibitor. Also provided are methods for inhibiting the growth of a tumor comprising a T790M EGFR mutation by contacting the tumor with an ErbB3 inhibitor and an EGFR inhibitor. Compositions for overcoming resistance to an ErbB pathway inhibitor, comprising both an ErbB 3 inhibitor and a second ErbB pathway inhibitor, such as an EGFR inhibitor or a HER2 inhibitor, are also provided.
