A patient interface includes a cushioning structure including at least one hollow chamber filled with first and second discrete and/or layered filling materials and a seal forming structure formed in one piece with the cushioning structure. The seal forming structure includes a thin membrane flap that is structured to provide a seal to the patient's face. The chamber extends only around a portion of the perimeter of the cushioning structure such that the chamber with first and second filling materials is provided in cheek and lip regions of the cushioning structure and a solid silicone portion is provided in a nasal bridge region of the cushioning structure.
