A compound of Formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, for use in the acute or prophylactic treatment of migraine headache or cluster headache together with one or more agents selected from: an anti-migraine agent； a 5-HT1B / 1D agonist； a 5-HT1D agonist； a 5-HT1F agonist； a cyclooxygenase inhibitor； a non-steroidal anti-inflammatory agent or a cytokine suppressor anti-inflammatory agent； a glucocorticoid and an analgesic； wherein: X is selected from -C (R8)>； = or -N>； =, where R8 is hydrogen, F or CN； R1 is selected from the group consisting of: C1-4 alkyl, cyclopropylmethyl, cyclobutylmethyl and [1- (trifluoromethyl) cyclopropyl] methyl, each of which is optionally substituted with one or more substituents as allowed by valence, selected independently among the group consisting of: F and hydroxyl； R2 is selected from hydrogen and methyl； when R2 is hydrogen then R3 is selected from hydrogen, F or Cl； R4 is selected from hydrogen, F or Cl； R5 is hydrogen； R6 is selected from hydrogen or F； and R7 is selected from hydrogen, F or Cl； except that at least two of R3, R4, R6 and R7 must be F or Cl, unless R3 is F in which case R4, R6 and R7 can all be hydrogen； and if R4 is Cl then R7 cannot be Cl； when R2 is methyl then R3 is selected from hydrogen, methyl, F, Cl or Br； R4 is selected from hydrogen, methyl, F or Cl； R5 is selected from hydrogen or F； R6 is selected from hydrogen or F； and R7 is selected from hydrogen, methyl, F or Cl； except that if R5 is F then at least three of R3, R4, R6 and R7 must be F； and if R4 is methyl or Cl then R7 cannot be methyl or Cl.Un compuesto de Fórmula I:**Fórmula** o una sal farmacéuticamente aceptable del mismo, para su uso en el tratamiento agudo o profiláctico de cefalea migrañosa o cefalea en racimo junto con uno o más agentes seleccionados entre: un agente anti-migraña； un agonista de 5-HT1B/1D； un agonista de 5-HT1D； un agonista de 5-HT1F； un inhibidor de la ciclooxigenasa； un agente anti-in
