Thioredoxin interacting protein (TXNIP) as regulator of vascular function

• 收藏
• 分享

专利权人:

Bradford C. Berk

发明人:

Bradford C. Berk

申请号：

US11814442

公开号：

US08999944B2

申请日:

2006.01.20

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The present invention relates to screening assays for the identification of agents that can modify the interaction of thioredoxin interacting protein (TXNEP) on thioredoxin (TRX)5 preferably by inhibiting TXNIP downregulation of TXR. The use of such compounds, including the disclosed siRNA and antibodies against TXNIP, is contemplated for therapeutic or prophylactic treatment of vascular disease conditions, particularly those associated with pro-inflammatory activity of the TNF-ASK1-JNK-p38 pathways.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/