PROBLEM TO BE SOLVED: To provide new compounds having immunomodulating activities and synthetic intermediates useful for production of these new compounds and particularly macrolide immunomodulators, and semisynthetic analogs of rapamycin and to provide a method for producing the semisynthetic analog and to provide a pharmaceutical composition containing the above compounds and to provide a therapeutic method using those.SOLUTION: The present invention provides new macrolide compounds, semisynthetic analogs of rapamycin and pharmaceutically acceptable salts, esters, amides and pro-drugs thereof and provides methods for producing the compounds and provides intermediates useful in these methods and a pharmaceutical composition, and provides a method of treating immunomodulatory disorders.COPYRIGHT: (C)2008,JPO&INPIT【課題】免疫調節活性を有する新規な化合物およびその新規化合物の製造に有用な合成中間体、およびとくにマクロライド免疫調節剤に関する。ラパマイシン(rapamycin)の半合成類似体、それらの製造方法、そのような化合物を含む薬剤組成物、およびそれらを用いる治療方法の提供。【解決手段】新規なマクロライド化合物、ラパミシンの半合成類似体、およびそれらの薬学的に許容し得る塩、エステル、アミドおよびプロドラッグ、本発明の化合物の製造方法、これらの方法に有用な中間体、薬剤組成物、および免疫調節疾患の治療方法。【選択図】なし
