Andrew Catanzaro,Robert Yarchoan,Jay A. Berzofsky,Takahiro Okazaki,James T. Snyder, II,Samuel Broder
申请号：
US11816704
公开号：
US09474793B2
申请日:
2006.02.22
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides methods for lowering a viral load of a virus resistant to an antiviral drug by inducing cytotoxic T lymphocytes (CTL) to recognize a predetermined mutated epitope within a viral protein of the drug-resistant virus. CTLs are induced by immunizing a host with a peptide comprising the predetermined mutation. The immunostimulating peptide may be further improved by epitope-enhancement for inducing specific CTLs. The antiviral protection against drug-resistant virus shown by compositions of the present invention and mediated by human HLA-restricted CTL has not been previously achieved.
