Frank Bedu-Addo,Greg Conn,Siva K. Gandhapudi,Martin Ward,Jerold Woodward
申请号：
US15725984
公开号：
US20180221475A1
申请日:
2017.10.05
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Methods and compositions for altering the microenvironment of a tumor are provided. The methods comprise reducing the population of tumor-residing immune suppressive regulatory T-cells, increasing the population of tumor lysing T-cells (such as CD8+ T-cells) and improving the efficacy of cancer immunotherapy. The compositions comprise the use of cationic lipids optionally combined with autologous antigens, non-autologous antigens, or tumor-associated antigens.
