William C. Olson;Robert J. Israel;Dangshe Ma;Stephen Morris
发明人:
Dangshe Ma,William C. Olson,Stephen Morris,Robert J. Israel
申请号：
US13030105
公开号：
US09242012B2
申请日:
2011.02.17
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Methods of killing prostate-specific membrane antigen (PSMA)-expressing, taxane-resistant cancer cells are provided. In particular, PSMA-expressing, taxane-resistant cancer cells are contacted with an antibody-drug conjugate (ADC) that comprises an antibody or antigen-binding fragment thereof that specifically binds to PSMA conjugated to monomethylauristatin norephedrine or monomethylauristatin phenylalanine.
