isolated caninized antibody or antigen binding fragment thereof, isolated nucleic acid, expression vector, host cell, pharmaceutical composition, and methods for enhancing the activity of an immune cell and for producing a caninized antibody or antigen binding fragment the same
DENISE BARTELS-MOROZOV,IAN TARPEY,JASON ERSKINE,LEONARD G. PRESTA,MOHAMAD MORSEY,YUANZHENG ZHANG
申请号：
BR112016014284
公开号：
BR112016014284A2
申请日:
2014.12.19
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The present invention provides caninized human anti-pd-1 murine antibodies that have specific sequences and a high binding affinity for canine pd-1. The invention also relates to the use of these antibodies in the treatment of dogs.a presente invenção provê anticorpos de murino anti-pd-1 humano caninizados que têm sequências específicas e uma alta afinidade de ligação para pd-1 canino. a invenção também se refere ao uso destes anticorpos no tratamento de cães.
