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PROCEDÉ DE PRODUCTION D'ACIDE HYALURONIQUE MODIFIÉ SOLUBLE DANS L'EAU
专利权人:
CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人:
申请号:
EP05782114.2
公开号:
EP1790665B1
申请日:
2005.09.07
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The present invention provides a water-soluble modified HA practically used as a drug carrier and a production method thereof. The present invention provides: a water-soluble modified hyaluronic acid, the residence time in blood of which is elongated to a practical level, which is produced by introducing a substituent into the carboxy group of the glucuronic acid of hyaluronic acid or a derivative thereof, via an amide bond, at a lower limit of an introduction rate of 5 mole % or more, using a BOP condensing agent in an aprotic polar solvent; and a production method thereof. Moreover, by cross-linking the modified hyaluronic acid, the present invention provides a hyaluronic acid gel capable of extremely long drug sustained-release even at the same cross-linking functional group introduction rate as that of the conventionally known gel.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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