A handle for a medical implant delivery system, comprising a front handle (8) and a rear handle (16). The front handle (8) and the rear handle (16) are internally provided with a guide rod (1). A sliding block (2) is provided on the guide rod (1). The front handle (8) and a handle rear end (15) are fixedly connected as a whole by means of the guide rod (1). The sliding block (2) and an outer tube (6) are fixedly connected as a whole by means of an outer tube connecting part. The sliding block (2) and the rear handle (16) are rotatably connected. The rear handle (16) uses an engagement slot of the front handle (8) and the handle rear end (15) as a pivot point to rotate, enabling the sliding block (2) to drive the outer tube (6) to slide on the guide rod (1). An anti-reverse rotation switch (17) and an anti-reverse rotation elastic plate (3) that limits a rotating direction of the rear handle (16) are provided at the point of connection of the front handle (8) and the rear handle (16). The handle uses a screw thread to implement rotation and release, converting a linear pulling force into a rotational torsion force, providing a better release feel and a safer and more stable release function. The anti-reverse rotation switch (17) and the anti-reverse rotation elastic plate (3) can prevent an error in a release step, thereby preventing misoperation and significantly improving product use safety.