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Aroyl-piperidine derivatives and method of treating disorders induced by substance P
专利权人:
Siem Jacob Veenstra
发明人:
Siem Jacob Veenstra
申请号:
US12690210
公开号:
US08193218B2
申请日:
2010.01.20
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The invention relates to a method of administering N-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-4-(quinoloylamino)-piperidines of the formulawherein Y is ═N— or ═N(O)—, R is OH when Y is ═N— and R is H when Y is ═N(O)— and the ring A is unsubstituted or mono- or poly-substituted by substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl, provided that when R is OH and Y is ═N— the ring A is not unsubstituted, for the treatment of disorders induced by substance P, such as: pain, migraines, anxiety, vomiting, schizophrenia, depression; motor disorders such as Parkinson's disease, inflammatory diseases such a rheumatoid arthritis, iritis and conjunctivitis, diseases of the respiratory organs such as asthma and chronic bronchitis, diseases of the gastrointestinal system such as ulcerative colitis and Crohn's disease, and hypertension.
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