KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
发明人:
SONG, JIE YOUNG,송지영,AHN, JI YEON,안지연,JUNG, IN SUNG,정인성,LEE, SAE LO OOM,이새로움,LIM, MIN JIN,임민진,KIM, MI HYOUNG,김미형
申请号：
KR1020120000656
公开号：
KR1020130079898A
申请日:
2012.01.03
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A composition containing a nuclear factor E2 factor related-factor 2 (Nrf2) activation inhibitor is provided to suppress the expression of a gene regulated by antioxidant response element (ARE) and to be used as an adjuvant for anticancer therapy for enhancing the effect of chemotherapy or radiotherapy.CONSTITUTION: An adjuvant composition for anticancer therapy contains a 4- (2-cyclohexylethoxy)aniline derivative of formula 1 or a pharmaceutically acceptable salt thereof. The anticancer therapy includes therapy using anticancer agents or radiotherapy. The derivative is a compound of formula 2, 3, 4, 5, or 6.COPYRIGHT KIPO 2013본 발명은 Nrf2 (Nuclear factor E2-factor related factor 2) 활성 억제제를 포함하는 항암치료 보조용 조성물에 관한 것이다.
