The present invention relates to a device for closing an opening in body tissue, comprising a first end section and a second end section both including one or more anchoring members, and a longitudinal axis. Both end sections are configured to transform in shape from a constrained configuration to an unconstrained configuration, wherein in the constrained configuration the one or more anchoring members are substantially parallel to the longitudinal axis, and in the unconstrained configuration the one or more anchoring members are substantially transverse to the longitudinal axis. The device further comprises a midsection coupled between the end sections, the midsection being self-biased to twist into at least one configuration that substantially prevents the flow of fluid therethrough.
