Embodiments of the present disclosure provide a method and a computing unit to monitor health condition of a subject. The computing unit receives physiological signals from a plurality of sensors placed on the subject. The computing unit detects a work-type based on the physiological signals received from the plurality of sensors and assigns a weight to each of the plurality of sensors based on the work-type. Thereafter, the computing unit generates a fatigue score using the physiological signals and the weight of the plurality of sensors. The fatigue score indicates the health condition of the subject.