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ENGINEERING STRUCTURALLY DEFINED NON-SACCHARIDE GLYCOSAMINOGLYCAN MIMETICS VIA A POLYPROLINE SCAFFOLD
专利权人:
AGENCY FOR SCIENCE; TECHNOLOGY AND RESEARCH
发明人:
Song-Gil LEE,Teck Chuan LIM,Shuting CAI,Su Seong LEE,Siv Ly KHOU,Kah Chin Jerry TOH,Joo-Eun JEE
申请号:
US15775354
公开号:
US20200291079A1
申请日:
2016.11.11
申请国别(地区):
US
年份:
2020
代理人:
摘要:
A non-saccharide glycosaminoglycan mimetic molecule comprising a polyproline backbone and one or more non-saccharide molecules, wherein the non-saccharide molecules are bound to one or more prolines and/or proline derivatives on the polyproline backbone, is disclosed herein. In a preferred embodiment the non-saccharide molecule is a negatively charged sulfate. The invention also relates to methods of synthesizing said non-saccharide glycosaminoglycan mimetic molecule and the use of the molecules thereof in targeting cell adhesion molecules such as selectin.
来源网站:
中国工程科技知识中心
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