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Methods for cryogenic storage
专利权人:
Juno Therapeutics, Inc.;Sara Church;Jon Gunther;Kathryn Pollock
发明人:
Church, Sara Elizabeth,Gunther, Jon Charles,Pollock, Kathryn
申请号:
AU2018234640
公开号:
AU2018234640A1
申请日:
2018.03.14
申请国别(地区):
AU
年份:
2019
代理人:
摘要:
The present disclosure relates to methods comprising cryogenically storing cells from a biological sample derived from a donor, in particular an apheresis sample, wherein the cells are frozen in a controlled rate freezer using a stepwise freezing profile comprising at least one step wherein the sample and/or chamber is cooled at a rate greater than 1° C per minute, and wherein the cells may comprise or be enriched for T cells. Further aspects relate e.g. to the point in time at which the cells are obtained from the donor, the storage time, shipping the cells to a storage facility before or after cryogenic freezing, the sample container being marked with codes or identifiers for cataloging the cells, administering a therapeutically effective amount of a composition comprising engineered T cells generated from the cryogenically frozen cells to a subject in need thereof; and treatment of the donor for a disease, in particular cancer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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