The present invention relates to a pyrido-aza heterocyclic compound represented by the following general formula I, an isomer thereof, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate, a process for producing the same, and a compound Compositions as well as their use in the manufacture of a medicament for treating protein kinases such as tumor diseases, in particular c-Met related disorders, as multi-target protein kinase inhibitors. Compounds of general formula I have effective inhibitory activity against c-Met kinase highly discovered tumor cells and can effectively target the c-Met mediated signaling pathway and c-And can be used for treating related diseases such as tumor due to Met kinase overexpression.Embedded image In general formula I
