Amarpreet S. Sawhney,Peter G. Edelman,Steven L. Bennett
申请号：
US10795132
公开号：
US08512749B2
申请日:
2004.03.05
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolution and nearly simultaneous crosslinking of the precursors, thus forming an insoluble hydrogel implant. The dehydrated precursor-based hydrogels may be used as sealants for fluid leaks from tissue, as adherent drug delivery depots, as means for augmenting and/or supporting tissue, and as means for serving a variety of other useful medical and surgical purposes.
