Robert G. Thorne,Michelle E. Pizzo,Daniel J. Wolak
申请号：
US15293925
公开号：
US10123969B2
申请日:
2016.10.14
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A method of enhancing therapeutic/drug transport to the perivascular space of the brain of a patient is disclosed. In one embodiment, the method comprises the step of introducing a therapeutic/drug and an osmolyte of the present invention into a patients cerebrospinal fluid (CSF), wherein the osmolyte is introduced to the CSF at a concentration of between 0.5 and 12.9 M (dependent on the solubility upper limit of the osmolyte), and wherein the therapeutic/drug delivery to the perivascular spaces of cerebral blood vessels and parenchyma of the central nervous system is facilitated by the presence of the osmolyte.
