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SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF
专利权人:
Shionogi &; Co.; Ltd.
发明人:
Makoto KAWAI,Kenji TOMITA,Toshiyuki AKIYAMA,Azusa OKANO,Masayoshi MIYAGAWA
申请号:
US16826623
公开号:
US20200283455A1
申请日:
2020.03.23
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention provides the following compounds having anti-viral activity.A1 is CR1AR1B, S or O;A2 is CR2AR2B, S or O;A3 is CR3AR3B, S or O;A4 is CR4AR4B, S or O;the number of hetero atoms among atoms constituting the ring which consists of A1, A2, A3, A4, nitrogen atom adjacent to A1 and carbon atom adjacent to A1, is 1 or 2;R1A and R1B are each independently hydrogen, halogen, alkyl, or the like;R2A and R2B are each independently hydrogen, halogen, alkyl, or the like;R3A and R3B are each independently hydrogen, halogen, alkyl, or the like;R4A and R4B are each independently hydrogen, halogen, alkyl, or the like;R3A and R3B may be taken together to form non-aromatic carbocycle or non-aromatic heterocycle;X is CH2, S or O;R1 is each independently halogen, hydroxy, or the like;m is any integer of 0 to 2; andn is any integer of 1 to 2.
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