The present invention provides an oral care composition comprising: (a) a dipeptide of the formula Xaa1-Xaa2 or Xaa2-Xaa1; wherein Xaa1 is an amino acid with a polar uncharged side chain; and Xaa2 is selected from an amino acid with a hydrophobic side chain, an amino acid with a polar uncharged side chain, and proline; or (b) a dipeptide of the formula Xaa3-Xaa4 or Xaa4-Xaa3; wherein Xaa3 is an amino acid with a hydrophobic side chain; and Xaa4 is selected from an amino acid with a hydrophobic side chain and an amino acid with a charged side chain.本發明係提供包括一口腔保健組成物,其包括:(a)式Xaa1-Xaa2或Xaa2-Xaa1之二肽;其中Xaa1為一含有極性不帶電側鏈之胺基酸;而Xaa2係選自含有疏水性側鏈之胺基酸、含有極性不帶電側鏈之胺基酸和脯胺酸;或(b)式Xaa3-Xaa4或Xaa4-Xaa3之二肽;其中Xaa3為一含有疏水性側鏈之胺基酸;而Xaa4係選自含有疏水性側鏈之胺基酸及含有帶電側鏈之胺基酸。