ШАХ Предиман К. (US),ЧИУ Куанг-Юх (US),ХОНДЗО Томоюки (US)
申请号：
RU2013126628/10
公开号：
RU2013126628A
申请日:
2011.11.11
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A method for the treatment and / or prevention of aneurysm and / or associated with her condition in a subject, wherein the method vklyuchaetvvedenie individual an effective amount of one or more of the immunogenic fragments of ApoB-100, or an immunogenically active part, wherein the immunogenic fragment comprises one of SEQ ID NO: 1-302, wherein one or more immunogenic fragments or their immunogenically active portion associated with a decrease ateroskleroza.2. The method of claim 1, wherein one or more immunogenic fragments contain one or more peptides wherein each contains one of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 11, SEQ ID NO: 25, SEQ ID NO : 45, SEQ ID NO: 74, SEQ ID NO: 99, SEQ ID NO: 100, SEQ ID NO: 102, SEQ ID NO: 103, SEQ ID NO: 105, SEQ ID NO: 129, SEQ ID NO: 143 , SEQ ID NO: 148, SEQ ID NO: 210 and SEQ ID NO: 301.3. The method of claim 1, wherein one or more immunogenic fragments contain one or more peptides wherein each contains one of SEQ ID NO: 2, SEQ ID NO: 11, SEQ ID NO: 45, SEQ ID NO: 74, SEQ ID NO : 102, SEQ ID NO: 148, SEQ ID NO: 162 and SEQ ID NO: 210.4. The method of claim 1, wherein one or more immunogenic fragments comprise a peptide having SEQ ID NO: 143 and peptide having SEQ ID NO: 210.5. The method of claim 1, wherein one or more immunogenic fragments comprise a peptide having SEQ ID NO: 11, the peptide having SEQ ID NO: 25 and peptide having SEQ ID NO: 74.6. The method of claim 1, wherein one or more immunogenic fragments comprise a peptide having SEQ ID NO: 2.7. The method of claim 1, wherein one or more immunogenic fragments comprise a peptide having SEQ ID NO: 45.8. The method of claim 1, wherein one or more immunogenic fragments comprise a peptide having SEQ ID NO: 210.9. The method of claim 1, wherein the individual is a cheloveka.10. The method of claim 1, wherein the administration is performed by administering a dose of at least 1 mg of 1 to 3 raz.11. The method of treatment and / or before1. Способ лечения и/или предотвра
