#$%^&*AU2016265959A120161215.pdf#####BIOACTIVE COMPOSITIONS COMPRISING FICUS SERUM FRACTION AND METHODS TO REDUCE THE APPEARANCE OF SKIN HYPERPIGMENTATION ABSTRACT The present invention provides bioactive compositions comprising Ficus serum fraction derived from Ficus cell juice of fresh Ficus leaves and a process of preparing the Ficus serum fraction. The compositions have biological activity capable of reducing skin hyperpigmentation.