The Children's Hospital of Philadelphia;The Childrens Hospital of Philadelphia
发明人:
Couto, Linda B.
申请号：
AU2011223820
公开号：
AU2011223820B2
申请日:
2011.03.01
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
Compositions and methods effective for modulating Hepatitis C viral infection are provided. Compositions and methods effective for modulating Hepatitis C viral infection are provided. Specifically, multiple artificial miRNAs targeting different regions of the HCV genome were inserted into a single promoter, polycistronic expression vector. The exogenous anti -HCV miRNAs induced gene silencing. When expressed from an adenovirus associated virus (AAV) delivery system, the vector inhibit the replication of HCV without inducing toxicity.
