Gopi M. Venkatesh,Ken Kangyi Qian,Shyam Vangala,James M. Clevenger,Donald Guenther
申请号：
US10827106
公开号：
US08545881B2
申请日:
2004.04.19
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A tablet that rapidly disintegrates in the oral cavity comprising a compressed blend of rapidly dispersing microgranules prepared by granulating a sugar alcohol or a saccharide or a mixture thereof having an average particle size less than about 30 microns and a disintegrant, and a taste-masked microcapsule containing at least one drug, the microcapsule being prepared by granulating a pharmaceutically acceptable formulation comprising at least one drug in a therapeutically effective amount and at least one polymeric binder that improves resilience of the microgranules, wet milling the granulated mass, and microencapsulating the milled granules to provide microcapsules.
