Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin

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专利权人:

John O. Trent

发明人:

John O. Trent,Paula J. Bates,Donald J. Miller

申请号：

US11982413

公开号：

US08114850B2

申请日:

2007.10.31

申请国别(地区):

US

年份:

2012

代理人:

摘要：

Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.

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