A prosthesis for placement relative to a carpal complex of a wrist can generally include a carpal implant having a body including an ulnar flange and a radial flange. The body can have a bone abutment surface and at least one flange extending from the bone abutment surface. The at least one flange can extend from the bone abutment surface a distance that spans at least one bone in an implanted position. The at least one flange can have a securing aperture that selectively receives a bone screw that advances into an identified bone of the carpal complex. A wrist bearing component can selectively mate with the carpal implant.