The present invention relates to 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidine derivatives and their use asP2Y12 receptor antagonists in the treatment and/or prevention of peripheralvascular, of visceral-, hepatic- and renal-vascular, ofcardiovascular and of cerebrovascular diseases or conditions associated withplatelet aggregation, including thrombosis in humansand other mammals.