CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA (CIGB)
发明人:
ABRAHANTES PEREZ, MARÍA DEL CARMEN,REYES GONZÁLEZ, JESÚS,VELIZ RÍOS, GLORIA,MARTÍNEZ DÍAZ, EDUARDO,GASMURI GONZÁLEZ, CARIDAD ANAIS,GARCÍA SUÁREZ, JOSÉ,BEQUET ROMERO, MÓNICA,GONZÁLEZ LÓPEZ, LUIS JAVIER,ABRAHANTES PEREZ MARIA DEL CARMEN,ABRAHANTES PEREZ MARÍA DEL CARMEN,REYES GONZALEZ JESUS,REYES GONZÁLEZ JESÚS,VELIZ RIOS GLORIA,VELIZ RÍOS GLORIA,MARTINEZ DIAZ EDUARDO,MARTÍNEZ DÍAZ EDUARDO,GASMURI GO
申请号：
PL05762122
公开号：
PL1787653T3
申请日:
2005.07.05
申请国别(地区):
PL
年份:
2012
代理人:
摘要：
The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from the internal metionine trough the end of the molecule, which could be combined among them and optionally with the prodigiosins that potentiate the antitumoral effect of the composition. The prodigiosins in the composition could be at a concentration of 0.1 - 100 nM. The anti-proliferative action of this composition is mediated by apoptotic mechanism. It's "in vivo" administration has antitumoral, antiangiogenic and protective effect against malignant tumors.
