NEW COMBINATION OF 4-{3-[CIS-HEXAHYDROCYCLOPENTA[C]PYRROL-2(1H)-YL]PROPOXY}BENZAMIDE AND ACETYLCHOLINESTERASE INHIBITOR, AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME
PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for use in treatment of cognitive disturbance relevant to brain aging and neurodegenerative disorder.SOLUTION: There is provided a combination of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}benzamide expressed by formula (I) or an addition salt thereof with a pharmacologically acceptable acid or base, and an acetylcholinesterase inhibitor. The acetylcholinesterase inhibitor is donepezil, rivastigmine or galantamine.【課題】脳の加齢及び神経変性疾患に関連する認知障害の処置における使用のための医薬組成物の提供。【解決手段】式(I):で示される4-{3-[cis-ヘキサヒドロシクロペンタ[c]ピロール-2(1H)-イル]プロポキシ}ベンズアミド、又は薬学的に許容しうる酸もしくは塩基とのその付加塩と、アセチルコリンエステラーゼ阻害剤との組み合わせ。アセチルコリンエステラーゼ阻害剤は、ドネペジル、リバスチグミン又はガランタミン。【選択図】なし