RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
发明人:
PARK, HYUN JU,박현주,SON, DO HYUN,손도현,LEE, KANG RO,이강노,WOO, KYEONG WAN,우경완,PARK, HYUN JUKR,SON, DO HYUNKR,LEE, KANG ROKR,WOO, KYEONG WANKR
申请号：
KR1020150002921
公开号：
KR1015439830000B1
申请日:
2015.01.08
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
The present invention relates to a composition including a novel histone deacetylase (HDAC) inhibitor derived from a natural material as an active ingredient for preventing, alleviating, or treating cancer. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating cancer and a health functional food composition for preventing or alleviating cancer which include 3,5-di-O-caffeoyl quinic acid methyl ester, which is a novel non-hydroxamate-based HDAC inhibitor compound derived from a natural material, and pharmaceutically acceptable salt thereof as active ingredients. The HDAC inhibitor of the present invention is a compound derived from a natural material, rarely has side effects, has an excellent anti-cancer effect, and thus can be advantageously used for the anti-cancer purpose.본 발명은 천연물에서 유래된 신규 히스톤 디아세틸라아제(HDAC) 억제제를 유효성분으로 포함하는, 암 예방, 개선, 또는 치료용 조성물에 관한 것으로, 보다 구체적으로, 본 발명은 천연물 유래 신규 비하이드록사메이트(non-hydroxamate)계 HDAC 억제제 화합물인 3,5-di-O-caffeoyl quinic acid methyl ester 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는, 암 예방 또는 치료용 약학적 조성물 및 암 예방 또는 개선용 건강 기능성 식품 조성물에 관한 것이다. 본 발명의 히스톤 디아세틸라아제 억제제는 천연물 유래 화합물로써 부작용이 거의 없고, 항암 효과가 뛰어나므로, 항암 용도로 유용하게 활용될 수 있다.
