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ANTICORPOS ANTI-EPCAM E MÉTODOS DE UTILIZAÇÃO
专利权人:
VIVENTIA BIO INC.
发明人:
JEANNICK CIZEAU,ARJUNE PREMSUKH,SHILPA CHOONIEDASS,GLEN MACDONALD,JOYCELYN ENTWISTLE
申请号:
PT14850812
公开号:
PT3052525T
申请日:
2014.10.02
申请国别(地区):
PT
年份:
2019
代理人:
摘要:
The present disclosure is related to compositions of antibodies and immunoconjugates that potentially lack T-cell epitopes and elicit reduced immune response. The antibody may be an antibody fragment, such as Fab, Fab′, F(ab′)2, scFv, dsFv, ds-scFv, dimers, minibodies, diabodies, bispecific antibody fragments, multimers, and any combination thereof. In a further embodiment, the antibody may bind to an antigen epithelial cell adhesion molecule (EpCAM). In another embodiment, an immunoconjugate may comprise an antibody attached to an effector molecule, wherein the effector molecule may be a radioisotope, an antineoplastic agent, an immunomodulator, a biological response modifier, lectin, a toxin, a chromophore, a fluorophore, a chemiluminescent compound, an enzyme, a metal ion, and any combination thereof.
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