BOEHME, THOMAS,波梅斯,波梅斯,GERLACH, UWE,盖拉奇,蓋拉奇,GRETZKE, DIRK,葛雷次,葛雷次,KLEEMANN, HEINZ-WERNER,克里曼,克里曼,PFEIFFER-MAREK, STEFANIA,菲佛尔,菲佛爾,VOLLERT, HENNING,沃乐特,沃樂特,ALTENBURGER, JEAN-MICHEL,阿藤宝,阿藤寶,MALLART, SER
申请号：
TW097120531
公开号：
TWI445526B
申请日:
2008.06.03
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The present invention relates to di(hetero)arylcyclohexane derivatives of the formula I,in which Ar1, Ar2, R1and R2have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds which inhibit ATP-sensitive potassium channels in the heart muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as arrhythmias or a decreased contractility of the heart, such as can occur, for example, in coronary heart disease, cardiac insufficiency or cardiomyopathies. In particular, they are suitable for the prevention of sudden cardiac death. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.本發明係有關一種式I二(雜)芳基環己烷衍生物其中Ar1、Ar2、R1與R2如申請專利範圍中之定義。式I化合物為可抑制心臟肌肉中ATP-敏感性鉀通道之有價值之醫藥活性化合物,適合例如:治療心血管系統之病變,如心律不整或心臟收縮力下降,如:可能發生在例如:冠狀動脈心臟病、心功能不足或心肌病變。特定言之,其適合用於預防心臟病猝死。本發明進一步有關製備式I化合物之方法及製備式I化合物之中間物、式I化合物之用途與含其之醫藥組成物。
