The present invention relates to a temperature difference slow release structure of active particles, which is mainly used to configure a particle coating on a substrate contacted with the receptor. The particle coating mainly comprises a plurality of central micelles, active bodies, and hydrophobic carriers, in which the particle coating may release the active bodies and the hydrophobic carriers while being stimulated to transfer the central micelles to the receptor. Since the substrate may be a general facial film, diaper, or patch, the particles may be affected by the temperature caused by contact with the receptor (human or animal) or the friction with the substrate to be released to the receptor. Thus, the present invention not only can enhance the convenience and comfort during usage, but also can achieve the slow release effect.本發明是一種活性微粒溫差緩釋結構，主要在用以接觸受體的基材上設置微粒塗層，微粒塗層主要包含複數中心微胞、活性體及疏水性載體，其中該微粒塗層受到一刺激狀態則釋放該活性體及該疏水性載體使各該中心微胞轉移至受體，由於基材可以為一般使用的面膜、尿布或貼布等，所以藉由受體(人或動物)接觸產生溫度或是與基材產生的摩擦都可以影響微粒使其釋放至受體，不僅提升使用上的便利性及舒適性，最主要的是達到緩慢釋放的效果。
