Anticuerpo biespecifico que se liga especificamente a vegf humano y dll4 humano anticuerpo que se liga especificamente a vegf humano anticuerpo que se liga especificamente a dll4 humano molecula de polinucleotido que lo codifica vector celula metodo de produccion composicion farmaceutica que los comprende y sus usos para tratar cancer.
GURNEY, AUSTIN, L.,SATO, AARON, KEN,BOND, CHRISTOPHER, JOHN
申请号：
CL2014000725
公开号：
CL2014000725A1
申请日:
2014.03.24
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human VEGF, antibodies that specifically bind human DLL4, and bispecific antibodies that specifically bind human VEGF and/or human DLL4. The present invention further provides methods of using the agents to inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.ANTICUERPO BIESPECIFICO QUE SE LIGA ESPECIFICAMENTE A VEGF HUMANO Y DLL4 HUMANO ANTICUERPO QUE SE LIGA ESPECIFICAMENTE A VEGF HUMANO ANTICUERPO QUE SE LIGA ESPECIFICAMENTE A DLL4 HUMANO MOLECULA DE POLINUCLEOTIDO QUE LO CODIFICA VECTOR CELULA METODO DE PRODUCCION COMPOSICION FARMACEUTICA QUE LOS COMPRENDE Y SUS USOS PARA TRATAR CANCER.
