BOUILLOT ANNE MARIE JEANNE,DENIS ALEXIS,LIDDLE JOHN,MIRGUET OLIVIER,WALKER ANN LOUISE
申请号：
IN201717038468
公开号：
IN201717038468A
申请日:
2017.10.30
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
Compounds of formula (I) wherein: R is heteroaryl optionally substituted by methyl ethyl halo or =O and R is H methyl or ethyl. and salts thereof are KMO inhibitors and may be useful in the treatment of various disorders for example acute pancreatitis chronic kidney disease other conditions associated with systemic inflammatory response syndrome (SIRS) Huntington s disease Alzheimer s disease spinocerebellar ataxias Parkinson s disease AIDS dementia complex HIV infection amylotrophic lateral sclerosis (ALS) depression schizophrenia sepsis cardiovascular shock severe trauma acute lung injury acute respiratory distress syndrome acute cholecystitis severe burns pneumonia extensive surgical procedures ischemic bowel disease severe acute hepatic disease severe acute hepatic encephalopathy or acute renal failure.
