The California Institute for Biomedical Research;The Scripps Research Institute
发明人:
Chanhyuk KIM,Jun Y. AXUP,Hwayoung YUN,Peter G. SCHULTZ,Jennifer MA,Jiayin SHEN,Pengyu YANG
申请号:
US15268389
公开号:
US20170002076A1
申请日:
2016.09.16
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Methods, compositions and uses are provided for bispecific antibodies comprising one or more unnatural amino acids. The bispecific antibodies may bind to two or more different receptors, co-receptors, antigens, or cell markers on one or more cells. The bispecific antibodies may be used to treat a disease or condition (e.g., cancer, autoimmune disease, pathogenic infection, inflammatory disease). The bispecific antibodies may be used to modulate (e.g., stimulate or suppress) an immune response.