4-(2-AMINO-TETRAHYDRONAPHTHALENYL)PYRIMIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER, CONTAINING SAME AS ACTIVE INGREDIENT
Jong Yeon HWANG,Hyoung Rae KIM,Jae Du HA,Sung Yun CHO,Hee Jung JUNG,Pilho KIM,Chang Soo YUN,Chong Ock LEE,Chi Hoon PARK,Chong Hak CHAE,Sunjoo AHN
申请号：
US15567224
公开号：
US20180104242A1
申请日:
2015.12.30
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a 4-(2-amino-tetrahydronaphthaleneyl)pyrimidine derivative, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of cancer comprising the same as an active ingredient. The 4-(2-amino-tetrahydronaphthaleneyl)pyrimidine derivative, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of the present invention is very effective in suppressing anaplastic lymphoma kinase (ALK) activity and as a result it can improve the effectiveness of treatment on cancer cells having anaplastic lymphoma kinase (ALK) fusion proteins such as EML4-ALK and NPM-ALK, so that it can be effectively used as a pharmaceutical composition for preventing or treating cancer.
