Haystead Timothy A. J.,Bodoor Khaldon,Hughes Philip F.
申请号：
US201515128825
公开号：
US10000469(B2)
申请日:
2015.03.25
申请国别(地区):
美国
年份:
2018
代理人:
Michael Best & Friedrich LLP
摘要：
Inducible HSP70 is overexpressed in a wide spectrum of human tumors and its expression correlates with metastasis and poor outcomes to radiation and chemotherapy in patients. Identification of small molecule inhibitors of HSP70 pose a new therapy to cancer treatment. HS72, a benzimidazole piperidinyl carboxamide has been identified as an allosteric inhibitor for HSP70 and has demonstrated good tumor growth inhibition in vivo.
