With piridilo substituted alkylamido compounds useful as modulators of cytokine responses and 23 heterodimericas Interleukin 12 (il-12 and il-23) and \/ or interferon alpha (ifnalfa)
LIU, CHUNJIAN,MERTZMAN, MICHAEL E.,MOSLIN, RYAN M.,ZHANG, YANLEI,WEINSTEIN, DAVID S.,WROBLESKI, STEPHEN T.,TOKARSKI, JOHN S.
申请号：
PE0006032016
公开号：
PE09612016A1
申请日:
2014.01.16
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
The present Invention relates to substituted alkylamido piridilo with Derivatives of formula (i) which act as modulators of responses heterodimericas cytokines interleukin 12 and 23 (IL - 12 andIl - 23) and \/ or interferon alpha. Where R1 is alquiloc1 replaced by 0 - 3 - 7 deuterium Atoms R2 is Methyl, Ethyl, etc. R3 has the formula (ii) r3aa is alquiloc1 - 6, etc.R3ac r3ab, or r3ad are Hydrogen, pirazolilo, etc. R4 and R5 are HydrogenLa presente invencion se refiere a derivados de piridilo sustituidos con alquilamida de formula (I) que actuan como moduladores de respuestas de citosinas heterodimericas Interleucina 12 y 23 (IL-12 e IL-23) y/o Interferon alfa. Donde: R1 es alquiloC1-3 sustituido por 0-7 atomos de deuterio R2 es metilo, etilo, etc. R3 tiene la formula (ii) R3aa es alquiloC1-6, etc. R3ab, R3ac o R3ad son hidrogeno, pirazolilo, etc. R4 y R5 son hidrogeno
