Levi A. Garraway,Caroline Emery,Carlos Garcia-Echeverria
申请号：
US13139060
公开号：
US09084781B2
申请日:
2009.12.10
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to methods, compositions and kits concerning resistance to treatment with an anti-cancer agent, specifically an inhibitor of MEK. In particular embodiments, the invention concerns mutations in a MEK sequence that confer resistance to a MEK inhibitor. Identification of such mutations in a MEK sequence allows the identification and design of second-generation MEK inhibitors. Methods and kits for detecting the presence of a mutant MEK sequence in a sample are also provided.
