The present invention relates to a hydroxy radical generation induction polymer containing a cinnamaldehyde derivative and an aminomalcocene derivative, which comprises a cinnamic aldehyde derivative, a poly (beta -amino ester) substituted with an aminomethacrolein derivative, a cinnamic aldehyde derivative, (Amidoamine) substituted with a carboxylic acid derivative or a copolymer thereof, and a polyethylene glycol-based compound having hydrophilicity, thereby allowing micelle formation. The structure of the micelle reacts sensitively to the pH change, and collapses under the environment of weakly acidic cancer tissues when the acetal bond is broken, and is encapsulated inside the micelle to release the cinnamaldehyde derivative and the aminometallocene derivative bound to the polymer main chain . Under acidic conditions, cinnamic aldehyde derivatives produce hydrogen peroxide and the aminomalcocene derivative reacts with hydrogen peroxide to produce highly toxic hydroxyl radicals, which will kill cancer cells. Thus, unlike the conventional drug delivery system using biodegradable polymers, the polymer itself can be used as a therapeutic drug, and it can capture other drugs through the micelle structure and accumulate specifically in the cancer site. Therefore, it has an effect of minimizing the toxicity to normal cells, while enhancing the effect of the anticancer oxidation treatment through the synergistic action of the cinnamaldehyde derivative which induces the hydrogen peroxide generation and the aminometallocene derivative which generates the hydroxyl radical. Through such a mechanism, polyCAFE has excellent biochemical activity of the polymer itself and exhibits a high anticancer effect as it decomposes under physiological conditions. In addition, polyCAFE has an advantage that it can be used as a cancer tissue sensitizing drug delivery vehicle when existing anticancer drugs are encapsulated.본 발명 신남알데하이드 유도체와 아미노 메탈로센 유도체가 함유된 하이드록시 라디칼 생성 유도 고분자에 관한 것으로, 신남알
