This disclosure provides anti-CXCR5 antibodies and their use in the amelioration, treatment, or prevention of lupus. The disclosure also provides prophylactic, immunotherapeutic, and diagnostic compositions comprising an anti-CXCR5 antibody, and the use of such anti-CXCR5 antibodies in methods of preventing or treating lupus in mammals, including humans.本揭示文係提供抗-CXCR5抗體及其於改善、治療或預防狼瘡之用途。本揭示文亦提供包括一抗-CXCR5抗體之預防性、免疫治療性及診斷性組成成物,以及此等抗-CXCR5抗體於哺乳動物(包括人類)中防止或治療狼瘡之方法上的用途。